I dont even want to touch my ball python anymore?

well hes not in shed just shedded, not hungry, temp, humidy is all ok and ive had him about 2 months and hes always been biteing well ive been handled him everyday to tame him and today he was started to be friendly it seemed like and i was like cool hes starting to tolerate it and about that time boom he tryes biting my thumb and he bit his self and he tryed to keep biteing but the last couple days he didnt try that but he is always in strike mode when handling him not like my buddys and be all friendly and loves being out. also when u put him back in tank he just sets there where u left him and doest move hes just physco